The porcine kidney cells Dr Church used for his experiments had 62 PERVs embedded (嵌入,植入)in their genomes. He and his colleagues tested their molecular scissors on several lines of these cells. In the most responsive, they managed to snip out (剪掉)all 62 copies of the integration gene.
Since PERVs rely on this gene to infect human cells as well as porcine ones, deleting it should stop them jumping into human hosts. Sure enough, tests in Petri dishes (皮氏培养皿)showed that the modified pig cells did not infect human cells grown alongside them. And, despite the extensive edits made to their DNA, those pig cells seemed unharmed by the procedure.
The editing would need to be done to sex cells, or their precursors(先导细胞), if actual lines of “clean” pigs were to be bred for use as organ donors. But this is still a striking result. Not only does it demonstrate that it is possible to cleanse(清洗) animal cells of unwanted viral passengers, thus helping remove one of the big barriers to cross-species organ transplants; it also shows the power of a genetic-engineering technique that has existed for only three years. (它不仅展示了我们可以将不需要的病毒过客从动物细胞中清洗出去,从而有助于解决跨物种器官移植的大障碍;还展示了存在仅仅三年的基因工程技术的力量所在。)
Vocabulary
transplant 移植
kidney 肾
species 物种
stopgap 临时替代物
conversely 相反地
fetus 胎儿
immune system 免疫系统
tissue 组织
swap 交换
address 解决(问题)
eliminate 消灭
millennium 千年
molecule 分子
delete 删除
with a view to... 旨在做......
embed 嵌入
cleanse 清洗
Transplant引起的词汇
Transplant 移植
Transfer 转移;调动
Transparent 透明的
Transfuse 输血
Transport 运输
Transmit 传递,传播
transcribe 抄写;誊写
transient 短暂的;过渡的
transcend 超越;跨越
transgress 越过;违反
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